Metafilter. I am loving you so much right now.
I had totally forgotten about Nobody Scores!, the psychopathic, Dadaist comic from Brandon Bolt. And then you went and reminded me.
Like crazy people? Like watching them suffer? Do you like watching them die, or get sent to distant planets, or go on homicidal rampages, or get turned into cans of catfood, without any sort of canonical repercussions?
Jane Doe is the chief crazy of crazytown. Her eyes are perpetually wide, as if her uppers have just kicked in, and she refuses to be bound by the laws of human decency. It's no surprise, then that she has ludicrous adventures with her roommates: Sara P., a Dagny Taggert-wannabe constantly thwarted by the innate superiority of her officemate "Fucking Julie," and Beans, a pretentious artist who will stomp on the little people the moment he finds mainstream success. They harass each other, make the world safe for kindergarten teachers, write FBI/pedophile slashfic, witness the apocalypse (and its postgame),
There are lampoons of office culture, self-improvement, academics, politics, and the art world, but the true genius of Nobody Scores! is in its pacing. Brevity may be the soul of wit, but there's an appropriate insanity in the way many installments go on and on. Just when you think the story is about to end, they zig into a fresh bin of loony. There are also smaller (and sometimes sadder) entries to satisfy your need for amuse bouche (or amuse yeux, as the case may be).
Plus, it's the only comic where Albert Einstein fights Genghis Khan.